1. Dexter (Showtime)
Set in Miami, the series centers on Dexter Morgan (Michael C. Hall), a serial killer governed by a strict moral code who works for the Miami Metro Police Department as a blood spatter analyst. Dexter struggles between his need to uphold justice and his need to kill.
It is based on the novel Darkly Dreaming Dexter by Jeff Lindsay and adapted for television by Emmy Award-winning screenwriter James Manos, Jr.
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2. House (Fox)
House is based around Dr. Gregory House (British actor Hugh Laurie), an unconventional medical genius who heads a team of diagnosticians at the fictional Princeton-Plainsboro Teaching Hospital (PPTH) in New Jersey. The character has similarities to Sherlock Holmes: both are forensic geniuses, musicians, drug users, aloof, and largely friendless.
3. 30 Rock (NBC)
The series takes place behind the scenes of a fictional live sketch comedy series depicted as airing on NBC; the name "30 Rock" refers to the address of the GE Building where NBC Studios is located, 30 Rockefeller Plaza. The series has an ensemble cast that currently consists of 10 regular cast members, including Fey, Tracy Morgan, Jane Krakowski, Jack McBrayer, Scott Adsit, Judah Friedlander and Alec Baldwin.
4. Rescue Me (FX)
Rescue me is a firefighter drama that follows the character Tommy Gavin (Denis Leary) and his ever troublesome family as they deal with real life issues, either with post 9/11 trauma or domestic problems. Tommy has to struggle with the loss of his cousin and best friend Jimmy Keefe, who died on September 11, 2001, and frequently visits Tommy in visions.
5. How I Met Your Mother (CBS)
This show is about a group of friends and the narration of Ted Mosby, in the year 2030, as he recounts to his son and daughter the events that led to his meeting their mother. They keep the mother as a mystery as Ted goes through life with his best friends Marshall (Jason Segal), Barney (Neil Patrick Harris), Lily (Alysson Hannigan), and Robin (Cobie Smulders).